Abstract
According to the WHO, depression is the most common mental illness, with adults and the elderly, but also a significant number of adolescents or young people being affected worldwide, the disease being a major cause of disability, with a significant contribution to the overall burden of the disease at global level. Although Romania has low incidence and prevalence compared to other European countries, the upward trend over time must be taken into account, as well as the negative impact with serious future health implications and the increased risk of death by suicide or associated comorbidities that induces the need for sustained interventions aimed at minimizing the burden of disease on both the patient and the health system, and timely therapeutic interventions can effectively reduce costs for patients and society.