The Role of Diabetes Mellitus in Modifying the Inflamatory Profile in Pacients with Pulmonary Tuberculosis

Abstract

The coexistence of diabetes mellitus (DM) and tuberculosis (TB) represents a
significant global burden. DM recognized as a major risk factor for TB. This
study comprehensively reviews the immunological aspects of TB/DM comorbidity,
reflecting the impact of DM on TB pathogenesis and immune responses. It reveals
that high blood glucose levels in TB patients contribute to a reduction in innate
immune cells, compromised phagocytic function, and delayed antigen
presentation. These factors ultimately impair the clearance of Mycobacterium
tuberculosis (MTB) and delay adaptive immune responses.